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This distinction proved relevant in animal studies where PT-141 produced: Penile erections in rats and non-human primates following systemic administration Erections after direct injection into brain ventricles, confirming central site of action Effects that persisted even when peripheral vascular function was compromised Enhanced sexual motivation behaviors distinct from purely erectile responses Preclinical Animal Studies Sexual Behavior in Female Rodents Landmark research using female rats in pacing chambers demonstrated PT-141s selective effects on appetitive sexual behaviors

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The association between OS and RM was also supported by other studies (198, 201, 202)

Cette tude a t ralise en utilisant une transection contrle de la branche motrice du nerf priphrique fmoral dans un modle exprimental