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Description
Glutathione transporters are of utmost importance because they minimize the fluctuations in the GSH concentrations, as well as in the redox state of glutathione, in the different cellular compartments, while their synthesis, degradation and recycling act in a coordinated form

Thus, the ATP/ADP level was decreased, leading to the activation of K ATP , which in turn inhibit the seizure activity and reduce the excitatory injury (65)

The disruption of this balance can be linked to the production of excessive quantities of oxidizing molecules or to the inefficiency of antioxidant systems

Emerging evidence suggests that inhibition of the Nrf2/Keap1/ARE pathway provides chemotherapeutic effects against cancers including brain cancer [146, 154, 155]
