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Additionally, a study on malathion-exposed rats showed increased reactive oxidative stress species (ROS) and reduced hippocampal BDNF expression, providing further mechanistic support for the observed relationship between OP pesticide exposure and decreased BDNF levels (Figure 3, number 14, 15)

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Reproductive toxicology 2019, 85, 93103

they reported the mechanism of action for silibinin effect is through preventing EGFR phosphorylation and suppressing expression of COX-2, VEGF AND MMP-9