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The extract of Salvia officinalis can significantly reduce insulin levels and the homeostasis model assessment of insulin resistance in PCOS patients, and significantly increase the quantitative insulin sensitivity check index, thus improving insulin resistance markers (64)

Viral vectors are chosen for their high transduction efficiency, but challenges include immunogenicity, risks of insertional mutagenesis (with integrating vectors), and control of long-term expression [111,112,113,114,115,116]

A DNA library of 6,000 lanthipeptide precursors fused to the leader sequence of nisin A ( 21 ) was generated via combination of units of rotationally constrained fragments from 12 natural lanthipeptides