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, 53 using claudin-2-null mice, suggest that the loss of claudin-2 in colonic epithelium enhances susceptibility to the DSS-colitis complemented these findings

Coexpression of five RBPs, namely, hnRNPR , SAFB2 , SF3B3 , hnRNPA1 , and hnRNPL also partially suppressed the eye degeneration, whereas coexpression of the other six RBPs had no effect, and two RBPs enhanced the phenotypes (Figures 1A1D and Figure 1source data 2)

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This is because different tools are not only sensitive to different structural characteristics of the protein but also have different averaging properties