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Description
Research indicates that in a high-glucose environment, the synthesis of glycocalyx components is hindered due to the stimulation of inflammatory mediators and ROS secretion

doi: 10.1371/journal.pone.0085216

Neurosci Lett (2000) 289(3):2014

As a result, a new ferroptosis inhibition axis with GTP cyclohydrolase-1 (GCH1) as the core was finally determined, which was found to be mainly regulated by the GCH1/BH4/DHFR pathway, which also protected cells from ferroptosis in a GPX4-independent manner ( Figure 1D )
