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What you didnt count on, though, was that they come with side effects, one of which is constipation
E2 appears to exert anorexigenic effects, whereas P4 in the presence of E2 tends to increase appetite and preference for energy-dense foods, an effect further modulated by changes in leptin, ghrelin, peptide YY (PYY), and possibly central insulin signaling [114]
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Less-serious side effects may include headache, dizziness, leg pain, itching, or rash
