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Bempedoic acid has demonstrated benefit in statin-intolerant patients and may be considered as an alternative, while PCSK9 inhibitors and inclisiran are indicated in patients at high or very high CV risk not reaching LDL-C goals

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There is insufficient evidence to suggest that nucleoside analogs used in the treatment of HIV infection (i.e., zidovudine [AZT], didanosine [ddI], zalcitabine [ddC], and stavudine [d4T] or certain cancer chemotherapy agents (i.e., ifosfamide, cisplatin) increase the risk of secondary L-carnitine deficiency (135)