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A math tool for laboratory setup research use only

A 2010 New England Journal of Medicine trial by Falutz et al

Other pharmacological options include catechol-O-methyltransferase (COMT) inhibitors like entacapone and opicapone, which extend the half-life of levodopa, do not cross the BBB at all and primarily affect peripheral metabolism, providing no direct action in the brain 59

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