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The treatment of cultured mouse hepatocytes with TNF-alpha plus 0.25 or 0.5 mmol/L DEM leads to incremental cell death in the form of apoptosis associated with increased caspase activities, release of cytochrome c, and DNA laddering [81]
Upon stimulation, IL-6 is secreted by many additional cell types including macrophages, T cells, B cells, mast cells, glial cells, eosinophils, keratinocytes, and granulocytes
M.TjonE.KivisakkP.et al
