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Epigenetic modifications, such as mtDNA hypermethylation, impair mitochondrial gene expression and respiration, while decreased SIRT3 activity contributes to the loss of redox homeostasis in retinal endothelial cells ( Figure 2 illustrates recent findings regarding mitochondrial structural and functional dysregulation under hyperglycemic stress, including fission/fusion imbalance, impaired mitophagy, and persistent ROS amplification

Results GSTM2 was upregulated in hepatic tissues of mice fed HFD and MCDD The high-fat diet and methionine choline deficient diet were used to make hepatic steatosis

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To view a copy of this licence, visit About this article Cite this article Meng, T., He, D., Han, Z