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In spite of the relevant issues mentioned above, the development of the first commercially available drug delivery system and advances in knowledge about in vivo results are important steps forward toward optimized design of more efficient formulations
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In mouse models of DMD, it has been found that IGF1-LR3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis
doi: 10.1016/j.cimid.2021.101611 157 ShahbaziRYasavoli-SharahiHAlsadiNIsmailNMatarC
