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Il demeure au repos pendant 1 h dans une enceinte thermostate qui maintient la temprature rectale de l'animal 38 o C, tout au long de la manipulation.The animal is placed on a cork board, the left hind leg fixed at the level of the tibia using a trigger guard stabilizing the preparation

Cancer Discov 2013

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13 Additionally, lactylation of TFEB at lysine 91 in tissues of PDA patients prevents its interaction with the E3 ubiquitin ligase WWP2, reducing TFEB ubiquitination and degradation, and thereby increasing its activity and autophagy flux, contributing to pancreatic cancer