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246 , R13R31 (2020)

A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds
The proposed mechanisms include activation of the hypothalamicpituitaryadrenal (HPA) axis and the sympathetic nervous system, leading to altered cytokine profiles and immune dysregulation

This mechanism is likely due to the C-terminal domain of NCOA4 binding to the conserved surface arginine (R23) of FTH1 in phagocytic cells, subsequently facilitating its interaction with autophagosomes and autolysosomes (14)