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Furthermore, they are chemically unstable and highly sensitive to external factors such as light, heat, oxygen, and pH fluctuations, leading to substantial degradation during processing, storage, and gastrointestinal transit (915)

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First, autophagy plays a protective role by inhibiting oxidative damage and apoptosis in CuSO 4 -induced testicular injury and spermatogenesis disruption, and second, autophagy plays an adverse role by promoting ferroptosis, thus aggravating the toxicity caused by CuSO 4 [100]

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