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In both CKD and ESRD patients, several metabolic alterations, including acidosis, systemic inflammation and hormonal dysregulation, together with comorbidities and multidrug therapies, can lead to malnutrition with subsequent folic acid and vitamin B12 deficiency

RESULTS Time-Course of CIA in DBA/1J Mice The development of inflammation was assessed by scoring the clinical disease activity and measuring changes in paw volumes

Cagrilintide is engineered to reproduce this receptor-level activity while carrying structural modifications that confer an extended half-life, improving its stability for laboratory investigation