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A drug can not generally have an oral bioavailability value higher than its value for f H , and oral bioavailability can equal f H only when all of the drug escapes from the GI tract and is able to enter the portal circulation (i.e

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Correspondingly, dysregulation of systemic immunoinflammatory responses with central and peripheral release of cytokines and other acute phase mediators have been implicated in the neurotoxic effects of chronic MA use [see (13) for review]