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Enhanced TP53 Reactivation Disrupts MYC Transcriptional Program and Overcomes Venetoclax Resistance in Acute Myeloid Leukemias

for example, promoting the BBB penetration with enhanced cellular uptake in brain endothelial cells using a cell-penetrating peptides (Muolokwu et al., 2024) or ligands (Mittal et al., 2020), enabling brain-targeting for neurons (Kuo and Tsao, 2017

46,47 Epigenetically, melatonin may inhibit histone deacetylases (HDACs) and modulate miRNA expression to reverse age-associated proinflammatory gene silencing in senescent immune cells, restoring functional competence

10.1073/pnas.0902714106 129 MengY