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These discoveries pave the way for new macrophage-focused therapeutic strategies, including the precise stratification of patients using biomarkers from liquid biopsies (such as soluble SPP1 and MARCO) and the development of targeted drug delivery systems for the selective modulation of macrophage function, thus establishing a new paradigm for therapeutic interventions in pulmonary fibrosis with concomitant lung cancer

The average dietary intake of CoQ10 is very low, requiring supplementation

Experiments have shown that overexpression of BECN1 significantly increases levels of malondialdehyde (MDA), Fe 2+ , and ROS in cells, promoting the occurrence of ferroptosis induced by CaOx crystals

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