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For that, the proposed targets were comparatively evaluated and prioritized using a qualitative framework constituted by five parameters: validation level, druggability, selectivity, resistance liability, and availability of chemical matter (Table II)

In the veterinary market, a topical nutraceutical formulation has clinically demonstrated strong antioxidant activity while topical ARI Kinostat has received FDA provisional approval for treating diabetic cataracts

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Reduced cytokines/chemokines expression and alteration of white blood cell trafficking can impact on tumor microenvironment, another possible immune-mediated and anti-cancer effect of bromelain