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Nrf1 knockout mice die in utero but fetal hepatocytes and embryonal fibroblasts from these animals have lower GSH levels and are more susceptible to oxidative stress (Kwong et al., 1999

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As a result, the first conclusion we can obtain from these results is that more studies are necessary in order to evaluate potential combinatory treatments in order to delay or prevent AD, which, after all, is a multifactorial disease and might need to be treated through multiple targets

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