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Mitochondrial complex I proteins Ndufa3 and Ndufb3, apoptotic regulator Hax1, and complement protein C1qbp were down regulated in male APOE4 mice ( Figure 2B )

As a result, L-carnitine with antioxidant and antiapoptotic properties can reduce adverse effects of busulfan on plasma membrane, DNA and mitochondrial integrity through reduction of lipid peroxidation, DNA as well as protein oxidation and decrease busulfan- induced apoptosis

This would suggest that the neuroprotective properties of either enantiomer of huperzine do not have a direct relationship to their AChE inhibitory activities

For instance, in this study, the participants took a gram of carnitine daily for six months and saw significant increases in total and free levels compared to placebo