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3 Current therapies from an OS perspective Although multiple disease-modifying therapies (DMTs) are currently approved for MS, most primarily target peripheral immune activation and inflammatory cell trafficking rather than directly interrupting OS-driven injury within the CNS
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Future studies should focus on large-scale GWAS and whole-genome sequencing to identify more risk alleles, especially those contributing to individual susceptibility and disease variability
The reduction in PPAR expression could be linked to the absence of its physiological ligand or the suppression of the peroxisome proliferator response element (PPRE) [129, 130]
