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To this purpose, ciliotoxicity ex vivo studies on sheep nasal mucosa were conducted, monitoring for ciliary or epithelial damage, necrosis or hemorrhage in response to nanoparticle-mediated drug delivery [77]

The Effect of Copper Oxide Nanoparticles on Hepatic and Renal Toxicity in Domestic Rabbits. Journal of Nanostructures 14: 150155

1 Introduction Liver diseases are mainly categorized into alcoholic liver disease (ALD), nonalcoholic liver disease (NAFLD), autoimmune liver disease (AILD), liver injury, liver cancer, etc., according to different etiologies and pathogeneses ( Increasing evidence has shown that gut microbes are closely associated with the pathogenesis of liver diseases in general ( At present, clinically effective therapeutic regimens and strategies for liver diseases are far from sufficient, which makes it an urgent issue to explore novel drugs and promising therapeutic strategies to overcome the existing deficiencies

33 Metabolomics and statistical analyses These analyses were performed as described 36 and are extensively reported in the Online Supplementary Methods