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Importantly, due to its ecto-enzymatic activity, CD38 not only regulates intracellular and extracellular NAD homeostasis, but also modulates the availability of extracellular NAD and its metabolites [6, 57]

Moreover, the amount of B12 in the liver reflects its metabolic requirements, not storage

[23] [24] Antibiotics can disrupt gut flora and occasionally lead to Clostridioides difficile infection

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