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Description
Non-coding nuclear-enriched abundant transcript 2 (NEAT2) has dual roles in the inflammatory response and in the secretions of IL-6, TNF-, and IL-1 cytokines, during different signaling pathways [43]
Neuroinflammation in Parkinson's disease: a target for neuroprotection
Blackshields G, Sievers F, Shi W, Wilm A, Higgins DG (2010) Sequence embedding for fast construction of guide trees for multiple sequence alignment

We speculate that conformational movement causing a structural rearrangement of the flexible loop may bring these two Cys residues closer