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[DOI] [PubMed] [Google Scholar] 84.Fox J.H., Kama J.A., Lieberman G., Chopra R., Dorsey K., Chopra V., Volitakis I., Cherny R.A., Bush A.I., Hersch S

Superoxide is spontaneously or enzymatically converted to hydrogen peroxide, which can be further reduced by Fe(II) to generate hydroxyl radicals (via the Fenton reaction)

The GDH2 complex is not inhibited by GTP which allows astrocyte GDH2 to continue to function under conditions of intense excitatory neurotransmission allowing these cells to handle the increased loads of the neurotransmitter glutamate

Its essential for detoxification, immune function, DNA protection, and cellular repair