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We have recently reported that there is a local structural similarity between an WD40 loop and the N-terminal Lys residue in the client tail dibasic motif 72
In addition to these effects, the ketogenic diet may be promoting mitophagy through upregulation of HIF-1 despite normoxic conditions, as exhibited in investigations of rat brains on this diet, therefore leading to transcription of BNIP3 and BNIP3L (NIX) (Puchowicz et al., 2008
[DOI] [PubMed] [Google Scholar] 64.Ullah F., Liang A., Rangel A., Gyengesi E., Niedermayer G., Mnch G
Clin Cancer Res 23, 28562868 (2017)
