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Description
These results are going to be really important for these treatments moving forward

The proLOX is processed extracellularly by bone morphogenetic protein-1 (BMP-1), resulting in the release of the catalytic domain, a biologically active form of LOX (LOX)

All authors commented on previous versions of the manuscript, read, and approved the final manuscript

Ozden and his colleagues reported that SIRT3 deacetylates the Pyruvate Dehydrogenase E1 Subunit Alpha 1 (PDHA1) subunit of pyruvate dehydrogenase complex (PDC) at the K321 position, thereby increasing its activity, which reverses the Warburg effect as glucose consumption and lactate production are reduced [83]