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Co-ingestion of kava with prescription medications or over-the-counter products, including other herbal remedies that are metabolized with one or more of these enzymes, might result in elevated and potentially toxic concentrations of the co-administered agents or their metabolites (81)

Glutathione is an antioxidant that naturally occurs in your body

This triad forms a pathogenic axis that drives disease progression, particularly in severe and treatment-resistant cases, and presents novel opportunities for therapeutic intervention ( Figure 4 )