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NOX4 can generate and accumulate superoxide and hydrogen peroxide, thereby promoting lipid peroxidation and the onset of ferroptosis

Association of myeloperoxidase gene variation with carotid atherosclerosis in patients with essential hypertension

The results of the study showed that silymarin and MLE had strong antioxidant activity and were hepatoprotective against DcNa-induced hepatotoxicity

Clinical trials of folic acid supplementation in MS patients are also limited and showed improvement in Hcy levels, anemia, and quality of life of patients with relapsing-remitting MS with folic acid and vitamin B12 supplementation in one study [225] whereas no effect of folic acid supplementation was observed on disability of MS patients in another study [226]