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In addition to the above strategies, curcumin inhibits inflammation-related transcription factors by reducing the accumulation of ROS ( 3.3 Apoptosis inhibition Apoptosis, also called programmed cell death, is a highly regulated process that automatically eliminates damaged or unnecessary cells to maintain tissue homeostasis (Norton et al., 2024)

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This is observed during a critical period where spines normally mature and coincides with the disease onset in the mouse model