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A second hydrogen peroxide molecule acts as a reducing agent to regenerate the resting state enzyme, producing a molecule of oxygen and water.36 Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,37 however, at high concentrations it has been reported to be very deleterious to cells.38 Hence, the ability of CAT to effectively limit H2O2 concentration in cells underlines its importance in the aforementioned physiological processes as well as being a first line antioxidant defense enzyme

The ability of ASXL1 1-645 to engage with BRD4 and MLL3/4 may help in the recruitment to or stabilization of the BAP1 complex at specific genomic regions, i.e., at H3K4me3-rich active promoters through binding of BRD4, and at H3K4me1-rich active enhancers through binding of MLL4 10,38 (Fig

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