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A most preferred administration is by the oral route (i.e., ingestion)

doi:10.1002/jnr.10778 pmid:14598323 Jeske NA, Glucksman MJ, Roberts JL (2004) Metalloendopeptidase EC3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells

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Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
