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Aging, stress, and environmental toxins often increase the body's demand for glutathione beyond what diet alone can provide

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85 This is of particular importance because some xenobiotics might impact the GI microbiota physiology without inducing dysbiosis: indeed, when fresh human faecal samples were incubated with antibiotics or with host-targeted drugs, all host-targeted drugs resulted in significant alterations of microbial gene expression, including genes involved in xenobiotic metabolism, despite minimal short-term effects on microbial community structure

Challenges and advancements in the bioavailability of phytochemicals in cancer therapy