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Price DJ, Drewry DH, Schaller LT, Thompson BD, Reid PR, Maloney PR, et al

In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling

Mougari F, Guglielmetti L, Raskine L, Sermet-Gaudelus I, Veziris N, Cambau E

The different tolerance profile between the two lipase inhibitors, seems to be related to the physical form of the fat in the intestine (rather than the amount of fat) resulting from each medication