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Retinoic acid promotes differentiation of GABAergic neurons expressing dopamine receptors [132,133,179], and changes in PD include inhibition of retinoic acid-mediated neuronal differentiation [180]

The use of picosecond lasers with diffractive lens arrays may, in addition, alleviate related photoaging characteristics, and the effects may be maintained for a longer time

In patients with longer disease duration, the abundance of Fournierella and DTU089 (Ruminococcaceae) increased, while that of Roseburia (Lachnospiraceae) decreased

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