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Beyond cancer biology, DES(1-3) IGF-1 has been investigated in neuroprotection models, where its high potency and reduced IGFBP binding facilitate clean receptor activation in brain tissue preparations where IGFBP concentrations would otherwise limit native IGF-1 activity

doi: 10.1016/j.imbio.2011.04.001
Neuropsychopharmacology 42(8):16981705 Schmaal L, Veltman DJ, Nederveen A, van den Brink W, Goudriaan AE (2012) N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study
