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Processes of Bone Elongation Endochondral Ossification and Growth Plate Morphology The skeleton develops by means of two different mechanisms: (1) Intramembranous ossification, involving direct differentiation of mesenchyme cells to bone as with the development of the flat bones of the skull and (2) Endochondral ossification, occurring when mesenchyme cells condense and differentiate into cartilage tissue, which then is replaced by bone forming the vertebrae, ribs and limbs [5]
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Another common polymorphism is A1298C, which also diminishes the enzyme activity
