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Here we tested whether -toxin impedes G-CSF-mediated granulopoiesis and found that -toxin had no inhibitory effect on the production of G-CSF, but the toxin inhibited G-CSF-mediated cell proliferation of Ly-6G + neutrophils by inducing the degradation of G-CSFR

doi: 10.3389/fmed.2026.1768345 Received 15 December 2025 Revised 17 February 2026 Accepted 19 February 2026 Published 19 March 2026 Volume 13 - 2026 Edited by Weiren Luo, The Second Affiliated hospital of Southern University of Science and Technology, China Reviewed by Rachid Ait Addi, Cadi Ayyad University, Morocco Asem Shalaby, Sultan Qaboos University, Oman Updates Copyright 2026 Huang, Zhou, Chen, Huang, Mo, Zeng, Wu and Luo