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Research has shown that also the insulin-like growth factor 1 (IGF-1) haplotype plays a critical role in determining size differences in dogs, with smaller breeds exhibiting lower levels of IGF-1, which may contribute to their increased longevity [67]

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Passeron T, Lim HW, Goh CL, Kang HY, Ly F, Morita A, et al

Struble et al., 2016
