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doi: 10.1681/ASN.2017050523
- Uptake of PPanSH bypasses canonical CoA biosynthesis enzymes, most notably pantothenate kinase (PANK)
Timeline Insight: Most users begin noticing visible changes after 48 weeks of regular and paired lifestyle changes
Lysosomal accumulation was observed in SMCR8 deficient macrophages from Smcr8 /mice , possibly because of increased ROS (Mcalpine et al., 2018)
