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Studies have shown that hesperidin, which is detected in Juhua ( Chrysanthemum morifolium Ramat.), could downregulate the expression levels of senescence marker proteins (e.g., p53, p21, and p16), inhibit the IL6/STAT3, TGF-1/Smad3/AMPK, and IB/NF-B pathways, regulate the levels of TNF-, IL-1, and IL-6, and alleviate PF in BLM-induced mouse model (Zhou et al., 2019

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Forms to Consider: Magnesium Threonate (for the brain), Glycinate (calming), Citrate (digestive support) Benefits: Sleep quality, blood pressure control, insulin sensitivity, stress reduction Commonly seen as a fitness supplement, creatine is actually one of the most well-researched cognitive enhancers