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Furthermore, ribosomal protein S6 kinase alpha-3 (RSKs) down-regulates the expression of ERK signaling and mediates the regulation of mitogenic and stress-induced phosphorylation that causes unintentional growth, and mediates cellular proliferation, survival, and distinction by tempering mTOR signaling and suppressing the pro-apoptotic role of BAD and DAPK1 [55,56]

Is proline accumulation per se correlated with stress tolerance or is proline homeostasis a more critical issue

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We found that the PhenoAge age gap was significantly correlated with multiple organ age gaps, but only a small portion of the variance in any model was explained by another (Extended Data Fig