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Consistent with these, more recent findings show that alterations in amyloid biology represent the earliest detectable changes in the brain in familial AD and start in the brain more than 20 years prior to the onset of AD (Bateman et al , 2012)

An overview on therapeutics attenuating amyloid level in Alzheimers disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels

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However, the therapeutic response may not be uniform across all patient populations