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Contrarily, CD11b upregulation in Munc13-4-knockout (KO) neutrophils was normal in response to the chemotactic peptide fMLF, a physiological stimulus that signals from plasma membrane receptors, further supporting that CD11b plasma membrane upregulation in response to CpG depends on TLR9 activation at endosomes 16

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Conversely, an upregulated inflammatory state cannot be countered by anti-inflammatory mechanisms, thus encouraging the development of the disease (Komaroff 2017)

In contrast, the MCT-KD provided 80% from fat (including 25% from MCT oil), 1015% from protein, and 510% from carbohydrates