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One major outstanding question is why ferroptosis exists, and whether it is adaptive or indicative of a biochemical failure in cells
10.1016/j.tins.2022.01.005 Trends Neurosci
DJ-1/PfpI domain containing proteins in Dicots Out of 217 DJ-1 protein members, one hundred and seven proteins were found to be present in dicots (Table 1)
Nevertheless, clinically significant biomarkers have not been revealed in non-targeted metabolomics, and the primary issue is the large heterogeneity in metabolites amongst studies
