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Systemically, the effects protect organs exposed to ischemia, medication stress, or immune activation
S.DugarB.et al (2011)
doi: 10.1101/gad.256214.114 70 GuptaA.LutsenkoS
Other documented adverse effects include decreased appetite (which contributes to the therapeutic effect), fatigue, injection site reactions, dizziness, and modest increases in heart rate (typically 2-4 beats per minute)
