glutathione s transferases and drug resistance Frontiers glutathione S-transferase

10.3892/ijmm.2015.2440 19 BattagliniD.Siwicka-GierobaD.RoccoP

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Graphical Abstract 1 Introduction Asthma is a chronic inflammatory airway disease characterized by the combined action of innate and adaptive immune system cells

Its mechanism involves the use of high-energy ionizing radiation (IR) to induce DNA fragmentation in tumor cells and subsequent initiation of various intracellular signal transduction pathways, including oxidative stress, the inflammatory response, and apoptosis ( Therefore, strategies are needed to effectively kill radioresistant tumor cells and improve their sensitivity to radiotherapy