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In many cases, profound hypotension develops intraoperatively after 45 to 60 minutes as a result of decreased vascular responsiveness and decreased myocardial contractility and is often refractory to interventions such as fluid or vasopressor therapy.8, 18, 19 Whichever surgical procedure is chosen, it is clear that anesthesia time should be minimized and long-term medical management will be necessary

doi: 10.1016/s0014-5793(02)03670-0 118 LaPlanteJ

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J Immunol 183 : 46014608 Fitzpatrick AM, Holguin F, Teague WG, Brown LA 2008 Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma